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Mouse Anti-Human Bcl-xL-FITC
Mouse Anti-Human Bcl-xL-FITC from MyBioSource.com
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Mouse Anti-Human Bcl-xL-FITC
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MyBioSource.com's
Mouse Anti-Human Bcl-xL-FITC
is a Mouse monoclonal antibody. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Product Specs
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Product Specs
Item
Mouse Anti-Human Bcl-xL-FITC
Company
MyBioSource.com
Price
Pricing Info
Supplier Page
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Catalog Number
MBS670002
Format
Fluorescein (FITC) Conjugate
Isotype
IgG3
Host
Mouse
Conjugate/Tag
FITC
Clone
7B2.5
Target
Bcl-xL
Immunogen
Human Bcl-xL (Mr 29 kDa)
Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems.1 It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment.2 Bcl- 2 and one of its homologues, Bcl-xL, protect cells from apoptosis3,4, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis.5-8 Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2.9-13 In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2,5,14 other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.15,16 Mab 7B2.5 recognizes both human and rodent Bcl-xL.17
Quantity
0.1 mg
Applications
Flow Cytometry; Immunohistochemistry; Immunoprecipitation; Western Blot
Reactivity
Human
Clonality
Monoclonal
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MyBioSource.com
P.O. Box 153308
San Diego
,
California
United States
Phone
: 1-888-627-0165 (toll free) or 1-858-633-0165
Fax: 1-858-633-0166
Email: sales@mybiosource.com
Company Profile
Website:
http://www.MyBioSource.com
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Mouse Anti-Human Bcl-xL-FITC from MyBioSource.com
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